Growing evidence suggests that many ribosome-targeting antibiotics inhibit protein synthesis context specifically, which has important implications for drug development. New work reveals the structural basis of context-specific action of the classic translation inhibitor chloramphenicol and the oxazolidinones linezolid and radezolid.
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References
Wilson, D. N. Nat. Rev. Microbiol. 12, 35–48 (2014).
Marks, J. et al. Proc. Natl Acad. Sci. USA 113, 12150–12155 (2016).
Choi, J. et al. Nat. Chem. Biol. 16, 310–317 (2020).
Orelle, C. et al. Antimicrob. Agents Chemother. 57, 5994–6004 (2013).
Syroegin, E. A. et al. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-022-00720-y (2022).
Tsai, K. et al. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-022-00723-9 (2022).
Sutcliffe, J. A. Ann. N.Y. Acad. Sci. 1241, 122–152 (2011).
Long, K., Poehlsgaard, J., Kehrenberg, C., Schwarz, S. & Vester, B. Antimicrob. Agents Chemother. 50, 2500–2505 (2006).
Mitcheltree, M. J. et al. Nature 599, 507–512 (2021).
Lovett, P. S. Gene 179, 157–162 (1996).
Ramu, H., Mankin, A. & Vazquez-Laslop, N. Mol. Microbiol. 71, 811–284 (2009).
Vazquez-Laslop, N. & Mankin, A. S. Annu. Rev. Microbiol. 72, 185–207 (2018).
Beckert, B. et al. Nat. Commun. 12, 4466 (2021).
Arenz, S. et al. Nat. Commun. 7, 12026 (2016).
Arenz, S. et al. Mol. Cell 56, 446–452 (2014).
Kannan, K. et al. Proc. Natl Acad. Sci. USA 111, 15958–15963 (2014).
Polikanov, Y. S., Steitz, T. A. & Innis, C. A. Nat. Struct. Mol. Biol. 21, 787–793 (2014).
Svetlov, M. S. et al. RNA 25, 600–606 (2019).
Wilson, D. N. et al. Proc. Natl Acad. Sci. USA 105, 13339–13344 (2008).
Wilson, D. N. & Beckmann, R. Curr. Opin. Struct. Biol. 21, 1–10 (2011).
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Crowe-McAuliffe, C., Wilson, D.N. Putting the antibiotics chloramphenicol and linezolid into context. Nat Struct Mol Biol 29, 79–81 (2022). https://doi.org/10.1038/s41594-022-00725-7
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DOI: https://doi.org/10.1038/s41594-022-00725-7
