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Can AlphaFold2 predict the impact of missense mutations on structure?

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Fig. 1: Interpretation of structure-disrupting mutations by AlphaFold2.


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We are grateful to H. Matsuo for critical reading of the manuscript. This work was supported by the Intramural Research Program of the Center for Cancer Research, National Cancer Institute, National Institutes of Health (NIH) (1ZIABC011627 to K.J.W.), and used computational resources of the High-Performance Computing Biowulf cluster of the NIH (

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Correspondence to Kylie J. Walters.

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Buel, G.R., Walters, K.J. Can AlphaFold2 predict the impact of missense mutations on structure?. Nat Struct Mol Biol 29, 1–2 (2022).

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