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HISTONE VARIANTS

MacroH2A1.1 has evolved to let PARP1 do more by loosening its grip on PAR

Nature Structural & Molecular Biology volume 28, pages 961–962 (2021)Cite this article

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This article has been updated

New work from Guberovic et al. sheds light on the evolution of the histone variant macroH2A1.1 and its relationship with the NAD+-using poly(ADP-ribose) polymerase PARP1. Their study shows that macroH2A1.1 has been a nuclear regulator of NAD+ flux as far back evolutionarily as pre-metazoan protists, but has been loosening the reins on PARP1, thus expanding PARP1’s cellular roles.

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Fig. 1: Ancestral eukaryotic macroH2A1.1 served as a potent regulator of nuclear NAD+ by tightly capping PAR chains.

BioRender.com.

Change history

  • 22 December 2021

    In the version of this article initially published, there was a typo in the last citation to the work of Guberovic et al. which has been corrected in the file as of 22 December 2021.

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Authors and Affiliations

  1. Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA

    Gregory A. Hamilton & Matthew J. Gamble

  2. Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY, USA

    Matthew J. Gamble

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  1. Gregory A. Hamilton
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  2. Matthew J. Gamble
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Correspondence to Matthew J. Gamble.

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Hamilton, G.A., Gamble, M.J. MacroH2A1.1 has evolved to let PARP1 do more by loosening its grip on PAR. Nat Struct Mol Biol 28, 961–962 (2021). https://doi.org/10.1038/s41594-021-00695-2

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  • DOI: https://doi.org/10.1038/s41594-021-00695-2

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