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Building insights into KRAS signaling complexes

The critical event in KRAS signaling and oncogenic transformation is activation of the RAF–MEK–MAPK cascade. This requires assembly of a multiprotein–lipid complex on the plasma membrane. In a tour de force of modeling, Mysore et al. now provide the first glimpse of what this structure may actually look like.

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Correspondence to John F. Hancock or Alemayehu A. Gorfe.

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Hancock, J.F., Gorfe, A.A. Building insights into KRAS signaling complexes. Nat Struct Mol Biol 28, 773–774 (2021).

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