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PHOSPHATASES

Pack a STRIPAK with hubs inside a hub

Nature Structural & Molecular Biology volume 28, pages 232–233 (2021)Cite this article

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The highly conserved striatin-interacting phosphatase and kinase (STRIPAK) multimeric complex regulates the Hippo signaling pathway through phosphatase activity. A recent structure of the core STRIPAK hub reveals how striatins tetramerize to serve as a scaffolding platform for the assembly of an intricate architecture, which is distinct from that of all other protein phosphatase 2A (PP2A) complexes.

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Fig. 1: Comparison of PP2A complexes from four major B subunit families.
Fig. 2: Mammalian Hippo signaling pathway.

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Authors and Affiliations

  1. Department of Pharmacology, Case Western Reserve University, Cleveland, OH, USA

    Wei Huang, Daniel Leonard & Derek J. Taylor

  2. Department of Biochemistry, Case Western Reserve University, Cleveland, OH, USA

    Derek J. Taylor

Authors
  1. Wei Huang
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  2. Daniel Leonard
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  3. Derek J. Taylor
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Correspondence to Derek J. Taylor.

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Competing interests

W.H., D.L. and D.J.T. provide consultation services to Rappta Therapeutics. D.J.T. has ownership interests in Rappta Therapeutics.

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Huang, W., Leonard, D. & Taylor, D.J. Pack a STRIPAK with hubs inside a hub. Nat Struct Mol Biol 28, 232–233 (2021). https://doi.org/10.1038/s41594-021-00571-z

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