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IMMUNOLOGY

Toll-like receptors form different complexes with UNC93B1

Nature Structural & Molecular Biology volume 28, pages 121–123 (2021)Cite this article

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The multipass transmembrane protein UNC93B1 is critical for the proper trafficking and function of many members of the Toll-like receptor (TLR) family of innate immune receptors. A new study reports two structures of UNC93B1 in complex with full-length TLR3 or TLR7 and sheds light on how this single chaperone may differentially interact with and regulate the function of individual TLRs.

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Fig. 1: Intracellular trafficking of TLRs by UNC93B1.
Fig. 2: Structure of UNC93B1 in complex with nucleic acid–sensing TLRs.

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Authors and Affiliations

  1. Division of Immunology & Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA

    Victoria E. Rael & Gregory M. Barton

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  1. Victoria E. Rael
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  2. Gregory M. Barton
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Correspondence to Gregory M. Barton.

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The authors declare no competing interests.

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Rael, V.E., Barton, G.M. Toll-like receptors form different complexes with UNC93B1. Nat Struct Mol Biol 28, 121–123 (2021). https://doi.org/10.1038/s41594-021-00559-9

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