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LEUKEMOGENESIS

Seeking commonalities in fusion proteins of NUP98

NUP98 is one of the most promiscuous fusion partners involved in leukemogenic chromosomal translocations, but the myriad of partners has long obfuscated the mechanism by which these fusion proteins drive leukemia. A new mass spectrometry–based approach has produced clues that suggest an entirely new model of leukemogenesis.

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Correspondence to Christopher I. Slape.

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Slape, C.I. Seeking commonalities in fusion proteins of NUP98. Nat Struct Mol Biol 28, 123–124 (2021). https://doi.org/10.1038/s41594-021-00558-w

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