Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

LEUKEMOGENESIS

Seeking commonalities in fusion proteins of NUP98

Nature Structural & Molecular Biology volume 28, pages123–124(2021)Cite this article

Subjects

NUP98 is one of the most promiscuous fusion partners involved in leukemogenic chromosomal translocations, but the myriad of partners has long obfuscated the mechanism by which these fusion proteins drive leukemia. A new mass spectrometry–based approach has produced clues that suggest an entirely new model of leukemogenesis.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

Rent or Buy

All prices are NET prices.

References

  1. 1.

    Michmerhuizen, N. L., Klco, J. M. & Mullighan, C. G. Blood 136, 2275–2289 (2020).

    Article  Google Scholar 

  2. 2.

    Terlecki-Zaniewicz, S. et al. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-020-00550-w (2021).

  3. 3.

    Boeynaems, S. et al. Proc. Natl Acad. Sci. USA 116, 7889–7898 (2019).

    CAS  Article  Google Scholar 

  4. 4.

    Wang, G. G. et al. Nature 459, 847–851 (2009).

    CAS  Article  Google Scholar 

  5. 5.

    Yassin, E. R., Abdul-Nabi, A. M., Takeda, A. & Yaseen, N. R. Leukemia 24, 1001–1011 (2010).

    CAS  Article  Google Scholar 

  6. 6.

    Fahrenkrog, B. et al. PLoS ONE 11, e0152321 (2016).

    Article  Google Scholar 

  7. 7.

    Radu, A., Moore, M. S. & Blobel, G. Cell 81, 215–222 (1995).

    CAS  Article  Google Scholar 

  8. 8.

    Capelson, M. et al. Cell 140, 372–383 (2010).

    CAS  Article  Google Scholar 

  9. 9.

    Franks, T. M. et al. Genes Dev. 31, 2222–2234 (2017).

    CAS  Article  Google Scholar 

  10. 10.

    Griffis, E. R., Craige, B., Dimaano, C., Ullman, K. S. & Powers, M. A. Mol. Biol. Cell 15, 1991–2002 (2004).

    CAS  Article  Google Scholar 

  11. 11.

    Hnisz, D., Shrinivas, K., Young, R. A., Chakraborty, A. K. & Sharp, P. A. Cell 169, 13–23 (2017).

    CAS  Article  Google Scholar 

  12. 12.

    Gibson, B. A. et al. Cell 179, 470–484.e21 (2019).

    CAS  Article  Google Scholar 

  13. 13.

    Sanulli, S. et al. Nature 575, 390–394 (2019).

    CAS  Article  Google Scholar 

  14. 14.

    Kim, S. & Shendure, J. Mol. Cell 76, 306–319 (2019).

    CAS  Article  Google Scholar 

  15. 15.

    Misteli, T. Cell 183, 28–45 (2020).

    CAS  Article  Google Scholar 

  16. 16.

    Shin, Y. & Brangwynne, C. P. Science 357, eaaf4382 (2017).

    Article  Google Scholar 

  17. 17.

    Banani, S. F., Lee, H. O., Hyman, A. A. & Rosen, M. K. Nat. Rev. Mol. Cell Biol. 18, 285–298 (2017).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

  1. The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, Queensland, Australia

    Christopher I. Slape

Authors
  1. Christopher I. Slape
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Christopher I. Slape.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Slape, C.I. Seeking commonalities in fusion proteins of NUP98. Nat Struct Mol Biol 28, 123–124 (2021). https://doi.org/10.1038/s41594-021-00558-w

Download citation

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing