Translation and mRNA decay are tightly connected processes governing protein production, and their regulation involves an elaborate network of protein factors and sequence elements. A massively parallel RNA-based reporter system now reveals regulatory pathways triggered by 5′ UTR elements and allows dissection of the interplay between translation and mRNA decay.
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12 August 2020
A Correction to this paper has been published: https://doi.org/10.1038/s41594-020-0491-8
References
Jia, L. et al. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-020-0465-x (2020).
Johnstone, T. G., Bazzini, A. A. & Giraldez, A. J. EMBO J. 35, 706–723 (2016).
Schmidt, C. et al. Science 354, 1431–1433 (2016).
Tesina, P. et al. Nat. Struct. Mol. Biol. 26, 275–280 (2019).
Buschauer, R. et al. Science 368, eaay6912 (2020).
Zaccara, S. & Jaffrey, S. R. Cell 181, 1582–1595.e18 (2020).
Tuck, A. C. et al. Mol. Cell 77, 1222–1236.e13 (2020).
D’Orazio, K. N. et al. Elife 8, e49117 (2019).
Guo, J. U. & Bartel, D. P. Science 353, aaf5371 (2016).
Melo, E. O., de Melo Neto, O. P. & Martins de Sá, C. FEBS Lett. 546, 329–334 (2003).
Ikeuchi, K. et al. EMBO J. 38, e100276 (2019).
Hondele, M. et al. Nature 573, 144–148 (2019).
Meyer, K. D. et al. Cell 163, 999–1010 (2015).
Van Nostrand, E. L. et al. Genome Biol. 21, 90 (2020).
Mao, Y. et al. Nat. Commun. 10, 5332 (2019).
Aeschimann, F. et al. Mol. Cell 65, 476–489.e4 (2017).
Bohlen, J., Fenzl, K., Kramer, G., Bukau, B. & Teleman, A. A. Mol. Cell https://doi.org/10.1016/j.molcel.2020.06.005 (2020).
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Bühler, M., Tuck, A.C. Scaling up dissection of functional RNA elements. Nat Struct Mol Biol 27, 771–773 (2020). https://doi.org/10.1038/s41594-020-0482-9
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DOI: https://doi.org/10.1038/s41594-020-0482-9