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STEM CELL DIFFERENTIATION

Dppa2 and Dppa4 safeguard bivalent chromatin in order to establish a pluripotent epigenome

Bivalent chromatin domains contain opposing histone modifications that assist cell lineage specification. Two studies report a role for Dppa2 and Dppa4 in the establishment of bivalency and the prevention of de novo DNA methylation at development-related genes in mouse embryonic stem cells.

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Fig. 1: Bivalent domains are established at Dppa2/4-bound promoters in ESCs.

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Correspondence to Eran Meshorer.

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Lim, P.S.L., Meshorer, E. Dppa2 and Dppa4 safeguard bivalent chromatin in order to establish a pluripotent epigenome. Nat Struct Mol Biol 27, 685–686 (2020). https://doi.org/10.1038/s41594-020-0453-1

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