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Phospholipid transporter shifts into reverse

The multisubunit phospholipid transport system Mla has been under scrutiny to determine whether it functions as an exporter or an importer. Structural studies accompanied by the reconstitution of the entire Mla system into proteoliposomes now reveal that ATP binding and hydrolysis drive phospholipid import.

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Fig. 1: Cell envelope phospholipid homeostasis defects in E. coli.

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Correspondence to Russell E. Bishop.

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Bishop, R.E. Phospholipid transporter shifts into reverse. Nat Struct Mol Biol 28, 8–10 (2021). https://doi.org/10.1038/s41594-020-00546-6

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