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Phospholipid transporter shifts into reverse

Nature Structural & Molecular Biology volume 28, pages 8–10 (2021)Cite this article

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The multisubunit phospholipid transport system Mla has been under scrutiny to determine whether it functions as an exporter or an importer. Structural studies accompanied by the reconstitution of the entire Mla system into proteoliposomes now reveal that ATP binding and hydrolysis drive phospholipid import.

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Fig. 1: Cell envelope phospholipid homeostasis defects in E. coli.

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Authors and Affiliations

  1. Department of Biochemistry and Biomedical Sciences and the Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON, Canada

    Russell E. Bishop

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  1. Russell E. Bishop
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Correspondence to Russell E. Bishop.

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The author declares no competing interests.

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Bishop, R.E. Phospholipid transporter shifts into reverse. Nat Struct Mol Biol 28, 8–10 (2021). https://doi.org/10.1038/s41594-020-00546-6

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