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ENZYMOLOGY

Flavin-containing monooxygenases: new structures from old proteins

A study reports the structures of membrane-bound flavin-containing monooxygenases (FMOs), solved using reconstructed ancestral mammalian FMOs. The models provide a structural basis for these enzymes’ mechanism of action and show how the proteins interact with membranes and how substrates access their active sites.

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Fig. 1: The catalytic cycle of mammalian FMOs.
Fig. 2: Schematic representation of tunnels within FMOs leading to the active site.

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Correspondence to Elizabeth A. Shephard.

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Phillips, I.R., Shephard, E.A. Flavin-containing monooxygenases: new structures from old proteins. Nat Struct Mol Biol 27, 3–4 (2020). https://doi.org/10.1038/s41594-019-0356-1

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