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DNA DAMAGE REPAIR

53BP1–RIF1: sculpting the DNA repair focus in 3D

Nature Structural & Molecular Biology volume 26, pages 1087–1088 (2019)Cite this article

Stabilization of the 3D genome architecture surrounding DNA lesions is critical for the maintenance of genome integrity. A new report by Ochs et al. shows how 53BP1 and RIF1 assemble a higher-order structure in the vicinity of damaged chromatin to protect it from unscheduled DNA-end resection.

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Fig. 1: Timeline for hierarchical assembly of 53BP1 MD after DSB induction.

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Author notes

  1. Evi Soutoglou

    Present address: Genome Damage and Stability center, Sussex University, School of Life Sciences, University of Sussex, Brighton, UK

Authors and Affiliations

  1. Institut de Génétique et de Biologie Moléculaire et Celullaire, Illkirch, France

    Indrajeet Ghodke & Evi Soutoglou

  2. Institut National de la Santé et de la Recherche Médicale, U964, Illkirch, France

    Indrajeet Ghodke & Evi Soutoglou

  3. Centre National de Recherche Scientifique, UMR7104, Illkirch, France

    Indrajeet Ghodke & Evi Soutoglou

  4. Université de Strasbourg, Strasbourg, France

    Indrajeet Ghodke & Evi Soutoglou

Authors
  1. Indrajeet Ghodke
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  2. Evi Soutoglou
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Correspondence to Evi Soutoglou.

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Ghodke, I., Soutoglou, E. 53BP1–RIF1: sculpting the DNA repair focus in 3D. Nat Struct Mol Biol 26, 1087–1088 (2019). https://doi.org/10.1038/s41594-019-0348-1

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