Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


53BP1–RIF1: sculpting the DNA repair focus in 3D

Stabilization of the 3D genome architecture surrounding DNA lesions is critical for the maintenance of genome integrity. A new report by Ochs et al. shows how 53BP1 and RIF1 assemble a higher-order structure in the vicinity of damaged chromatin to protect it from unscheduled DNA-end resection.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: Timeline for hierarchical assembly of 53BP1 MD after DSB induction.


  1. Chapman, J. R., Sossick, A. J., Boulton, S. J. & Jackson, S. P. J. Cell Sci. 125, 3529–3534 (2012).

    Article  CAS  Google Scholar 

  2. Ochs, F. Nature 574, 571–574 (2019).

    Article  CAS  Google Scholar 

  3. Noordermeer, S. M. et al. Nature 560, 117–121 (2018).

    Article  CAS  Google Scholar 

  4. Gupta, R. et al. Cell 173, 972–988.e23 (2018).

    Article  CAS  Google Scholar 

  5. Ghezraoui, H. et al. Nature 560, 122–127 (2018).

    Article  CAS  Google Scholar 

  6. Dev, H. et al. Nat. Cell Biol. 20, 954–965 (2018).

    Article  CAS  Google Scholar 

  7. Tomida, J. et al. EMBO J. 37, e99543 (2018).

    Article  Google Scholar 

  8. Mirman, Z. et al. Nature 560, 112–116 (2018).

    Article  CAS  Google Scholar 

  9. Barazas, M. et al. Cell Reports 23, 2107–2118 (2018).

    Article  CAS  Google Scholar 

  10. Szabo, Q., Bantignies, F. & Cavalli, G. Sci. Adv. 5, eaaw1668 (2019).

    Article  CAS  Google Scholar 

  11. Natale, F. et al. Nat. Commun. 8, 15760 (2017).

    Article  CAS  Google Scholar 

  12. Botuyan, M. V. et al. Cell 127, 1361–1373 (2006).

    Article  CAS  Google Scholar 

  13. Fradet-Turcotte, A. et al. Nature 499, 50–54 (2013).

    Article  CAS  Google Scholar 

  14. Pellegrino, S., Michelena, J., Teloni, F., Imhof, R. & Altmeyer, M. Cell Rep. 19, 1819–1831 (2017).

    Article  CAS  Google Scholar 

  15. Buonomo, S. B. C. Adv. Exp. Med. Biol. 1042, 259–272 (2017).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Evi Soutoglou.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Ghodke, I., Soutoglou, E. 53BP1–RIF1: sculpting the DNA repair focus in 3D. Nat Struct Mol Biol 26, 1087–1088 (2019).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing