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DNA DAMAGE REPAIR

53BP1–RIF1: sculpting the DNA repair focus in 3D

Stabilization of the 3D genome architecture surrounding DNA lesions is critical for the maintenance of genome integrity. A new report by Ochs et al. shows how 53BP1 and RIF1 assemble a higher-order structure in the vicinity of damaged chromatin to protect it from unscheduled DNA-end resection.

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Fig. 1: Timeline for hierarchical assembly of 53BP1 MD after DSB induction.

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Correspondence to Evi Soutoglou.

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Ghodke, I., Soutoglou, E. 53BP1–RIF1: sculpting the DNA repair focus in 3D. Nat Struct Mol Biol 26, 1087–1088 (2019). https://doi.org/10.1038/s41594-019-0348-1

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