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Structure of the P element transpososome reveals new twists on the DD(E/D) theme

The first structure of this unusual recombinase in complex with substrate DNAs reveals surprisingly unpaired and refolded transposon end DNAs that are positioned in part by direct interactions with a GTP cofactor.

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Fig. 1: P element transposition.
Fig. 2: Orthogonal views of the P element transpososome structure.
Fig. 3: Similarities among insertion domains.

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Correspondence to Phoebe A. Rice.

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Rice, P.A. Structure of the P element transpososome reveals new twists on the DD(E/D) theme. Nat Struct Mol Biol 26, 989–990 (2019). https://doi.org/10.1038/s41594-019-0329-4

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