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METABOLISM

Naa10P puts a brake on PGC1α and fat browning

Beige fat serves as a substantial metabolic sink that dissipates energy and has consequently attracted much attention as a target for improving metabolic health. A recent study has provided a new molecular target, the N-terminal acetyltransferase Naa10p, for harnessing beige-fat biogenesis and improving whole-body energy homeostasis1.

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Fig. 1: The biogenesis of beige fat.

References

  1. Lee, C.C. et al. Mol. Cell https://doi.org/10.1016/j.molcel.2019.07.026 (2019).

  2. Sidossis, L. & Kajimura, S. J. Clin. Invest. 125, 478–486 (2015).

    Article  Google Scholar 

  3. Inagaki, T., Sakai, J. & Kajimura, S. Nat. Rev. Mol. Cell Biol. 17, 480–495 (2016).

    CAS  Article  Google Scholar 

  4. Arch, J. R. Ther. Adv. Endocrinol. Metab. 2, 59–64 (2011).

    CAS  Article  Google Scholar 

  5. Rope, A. F. et al. Am. J. Hum. Genet. 89, 28–43 (2011).

    CAS  Article  Google Scholar 

  6. Lerin, C. et al. Cell Metab. 3, 429–438 (2006).

    CAS  Article  Google Scholar 

  7. Rodgers, J. T. et al. Nature 434, 113–118 (2005).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Shingo Kajimura.

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Wang, Q., Kajimura, S. Naa10P puts a brake on PGC1α and fat browning. Nat Struct Mol Biol 26, 849–851 (2019). https://doi.org/10.1038/s41594-019-0310-2

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