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Naa10P puts a brake on PGC1α and fat browning

Beige fat serves as a substantial metabolic sink that dissipates energy and has consequently attracted much attention as a target for improving metabolic health. A recent study has provided a new molecular target, the N-terminal acetyltransferase Naa10p, for harnessing beige-fat biogenesis and improving whole-body energy homeostasis1.

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Fig. 1: The biogenesis of beige fat.


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Correspondence to Shingo Kajimura.

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Wang, Q., Kajimura, S. Naa10P puts a brake on PGC1α and fat browning. Nat Struct Mol Biol 26, 849–851 (2019).

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