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METABOLISM

Naa10P puts a brake on PGC1α and fat browning

Nature Structural & Molecular Biology volume 26, pages 849–851 (2019)Cite this article

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Beige fat serves as a substantial metabolic sink that dissipates energy and has consequently attracted much attention as a target for improving metabolic health. A recent study has provided a new molecular target, the N-terminal acetyltransferase Naa10p, for harnessing beige-fat biogenesis and improving whole-body energy homeostasis1.

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Fig. 1: The biogenesis of beige fat.

References

  1. Lee, C.C. et al. Mol. Cell https://doi.org/10.1016/j.molcel.2019.07.026 (2019).

  2. Sidossis, L. & Kajimura, S. J. Clin. Invest. 125, 478–486 (2015).

    Article  Google Scholar 

  3. Inagaki, T., Sakai, J. & Kajimura, S. Nat. Rev. Mol. Cell Biol. 17, 480–495 (2016).

    Article  CAS  Google Scholar 

  4. Arch, J. R. Ther. Adv. Endocrinol. Metab. 2, 59–64 (2011).

    Article  CAS  Google Scholar 

  5. Rope, A. F. et al. Am. J. Hum. Genet. 89, 28–43 (2011).

    Article  CAS  Google Scholar 

  6. Lerin, C. et al. Cell Metab. 3, 429–438 (2006).

    Article  CAS  Google Scholar 

  7. Rodgers, J. T. et al. Nature 434, 113–118 (2005).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. UCSF Diabetes Center, San Francisco, CA, USA

    Qiang Wang & Shingo Kajimura

  2. Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, San Francisco, CA, USA

    Qiang Wang & Shingo Kajimura

  3. Department of Cell and Tissue Biology, University of California, San Francisco, CA, USA

    Qiang Wang & Shingo Kajimura

Authors
  1. Qiang Wang
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  2. Shingo Kajimura
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Correspondence to Shingo Kajimura.

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The authors declare no competing interests.

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Wang, Q., Kajimura, S. Naa10P puts a brake on PGC1α and fat browning. Nat Struct Mol Biol 26, 849–851 (2019). https://doi.org/10.1038/s41594-019-0310-2

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