GENE SILENCING

An RNA exporter that enforces a no-export policy

Small RNAs guide nuclear Argonaute proteins to silence genomic target loci via recruitment of factors that lead to formation of repressive heterochromatin. Animal gonads use this pathway to repress transposable elements with PIWI-clade Argonaute proteins and their associated small RNAs called PIWI-interacting RNAs (piRNAs). Four research groups now identify a protein complex that acts as a molecular bridge between the piRNA pathway and the epigenetic silencing machinery.

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Fig. 1: Nxf2 promotes co-transcriptional silencing of transposon loci in the fly germ line.

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Correspondence to Ramesh S. Pillai.

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Homolka, D., Pillai, R.S. An RNA exporter that enforces a no-export policy. Nat Struct Mol Biol 26, 758–759 (2019). https://doi.org/10.1038/s41594-019-0294-y

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