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GENE SILENCING

An RNA exporter that enforces a no-export policy

Nature Structural & Molecular Biology volume 26, pages 758–759 (2019)Cite this article

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Small RNAs guide nuclear Argonaute proteins to silence genomic target loci via recruitment of factors that lead to formation of repressive heterochromatin. Animal gonads use this pathway to repress transposable elements with PIWI-clade Argonaute proteins and their associated small RNAs called PIWI-interacting RNAs (piRNAs). Four research groups now identify a protein complex that acts as a molecular bridge between the piRNA pathway and the epigenetic silencing machinery.

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Fig. 1: Nxf2 promotes co-transcriptional silencing of transposon loci in the fly germ line.

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  1. Department of Molecular Biology, Science III, University of Geneva, Geneva, Switzerland

    David Homolka & Ramesh S. Pillai

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  1. David Homolka
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  2. Ramesh S. Pillai
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Correspondence to Ramesh S. Pillai.

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The authors declare no competing interests.

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Homolka, D., Pillai, R.S. An RNA exporter that enforces a no-export policy. Nat Struct Mol Biol 26, 758–759 (2019). https://doi.org/10.1038/s41594-019-0294-y

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