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Epigenetic drug target deconvolution by mass spectrometry–based technologies

Abstract

The identification of the full target spectrum of active molecules, known as target deconvolution, has become an indispensable step during the drug discovery process. It is now achievable thanks to mass spectrometry–based technologies. Here we discuss these approaches in the context of epigenetic drug discovery.

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Fig. 1: Applications of drug target deconvolution during the drug discovery process.
Fig. 2: MS-based drug target deconvolution strategies.

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Correspondence to Tiziana Bonaldi.

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Noberini, R., Bonaldi, T. Epigenetic drug target deconvolution by mass spectrometry–based technologies. Nat Struct Mol Biol 26, 854–857 (2019). https://doi.org/10.1038/s41594-019-0279-x

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