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Flu transcription captured in action

Viral mRNA synthesis is an essential step in the influenza virus replication cycle and is a prime target for the development of new antivirals. New structures of the influenza virus RNA polymerase now unveil previously unknown details of influenza virus transcription.

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References

  1. 1.

    Krug, R. M., Morgan, M. A. & Shatkin, A. J. J. Virol. 20, 45–53 (1976).

  2. 2.

    Etkind, P. R. & Krug, R. M. Virology 62, 38–45 (1974).

  3. 3.

    Decroly, E. & Canard, B. Curr. Opin. Virol. 24, 87–96 (2017).

  4. 4.

    Plotch, S. J., Bouloy, M., Ulmanen, I. & Krug, R. M. Cell 23, 847–858 (1981).

  5. 5.

    Kouba, T., Drncova, P. & Cusack, S. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-019-0232-z (2019).

  6. 6.

    Lukarska, M. et al. Nature 541, 117–121 (2017).

  7. 7.

    Serna Martin, I. et al. Mol. Cell 70, 1101–1110.e4 (2018).

  8. 8.

    Reich, S. et al. Nature 516, 361–366 (2014).

  9. 9.

    Koppstein, D., Ashour, J. & Bartel, D. P. Nucleic Acids Res. 43, 5052–5064 (2015).

  10. 10.

    Reich, S., Guilligay, D. & Cusack, S. Nucleic Acids Res. 45, 3353–3368 (2017).

  11. 11.

    Robb, N. C. et al. Nucleic Acids Res. 44, 10304–10315 (2016).

  12. 12.

    Robb, N., te Velthuis, A.J.W., Fodor, E. & Kapanidis, A.N. Nucleic Acids Res. https://doi.org/10.1093/nar/gkz313 (2019).

  13. 13.

    Pauly, M. D., Procario, M. C. & Lauring, A. S. eLife 6, e26437 (2017).

  14. 14.

    Goldhill, D. H. et al. Proc. Natl Acad. Sci. USA 115, 11613–11618 (2018).

  15. 15.

    te Velthuis, A. J. W., Robb, N. C., Kapanidis, A. N. & Fodor, E. Nat. Microbiol. 1, 16029 (2016).

  16. 16.

    Appleby, T. C. et al. Science 347, 771–775 (2015).

  17. 17.

    Laurila, M. R. L., Makeyev, E. V. & Bamford, D. H. J. Biol. Chem. 277, 17117–17124 (2002).

  18. 18.

    Klumpp, K., Ford, M. J. & Ruigrok, R. W. J. Gen. Virol. 79, 1033–1045 (1998).

  19. 19.

    Braam, J., Ulmanen, I. & Krug, R. M. Cell 34, 609–618 (1983).

  20. 20.

    Te Velthuis, A. J. W. et al. Nat. Microbiol. 3, 1234–1242 (2018).

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Acknowledgements

A.J.W.t.V. is supported by joint Wellcome Trust and Royal Society grant 206579/Z/17/Z and Isaac Newton Trust grant 17.37(r).

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Correspondence to Aartjan J. W. te Velthuis.

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Fig. 1: Stages of influenza virus transcription initiation.