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Insights into L-type heteromeric amino acid transporters

Two recent cryo-EM structures of the human L-type heteromeric amino acid transporter LAT1–CD98hc reveal surprising new insights into both amino acid transport in the human body and the roles of CD98hc as a cell-surface antigen and trafficking chaperone.

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Fig. 1: Physiological role of the LAT1–CD98hc heteromeric amino acid transporter.
Fig. 2: Structure of the LAT1–CD98hc complex.


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Correspondence to Simon Newstead.

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Newstead, S. Insights into L-type heteromeric amino acid transporters. Nat Struct Mol Biol 26, 395–396 (2019).

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