Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

TAUOPATHIES

Protein shapes at the core of chronic traumatic encephalopathy

A Publisher Correction to this article was published on 23 May 2019

This article has been updated

A recent cryo-EM study has generated breakthrough insights into the molecular and structural bases of tau tangles from individuals who died of CTE.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Fig. 1: Structures of tau filaments extracted from brains of people diagnosed with tauopathies.
Fig. 2: Cofactors might be part of the tau filament assembly process.

Change history

  • 23 May 2019

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

References

  1. Lee, V. M., Goedert, M. & Trojanowski, J. Q. Annu. Rev. Neurosci. 24, 1121–1159 (2001).

    Article  CAS  Google Scholar 

  2. McKee, A. C. et al. J. Neuropathol. Exp. Neurol. 68, 709–735 (2009).

    Article  Google Scholar 

  3. Clavaguera, F. et al. Nat. Cell Biol. 11, 909–913 (2009).

    Article  CAS  Google Scholar 

  4. Kaufman, S. K. et al. Neuron 92, 796–812 (2016).

    Article  CAS  Google Scholar 

  5. Narasimhan, S. et al. J. Neurosci. 37, 11406–11423 (2017).

    Article  CAS  Google Scholar 

  6. Walker, L. C., Diamond, M. I., Duff, K. E. & Hyman, B. T. JAMA Neurol. 70, 304–310 (2013).

    Article  Google Scholar 

  7. Woerman, A. L. et al. Proc. Natl Acad. Sci. USA 113, E8187–E8196 (2016).

    Article  CAS  Google Scholar 

  8. Fitzpatrick, A. W. P. et al. Nature 547, 185–190 (2017).

    Article  CAS  Google Scholar 

  9. Falcon, B. et al. Nature 561, 137–140 (2018).

    Article  CAS  Google Scholar 

  10. Falcon, B. et al. Nature https://doi.org/10.1038/s41586-019-1026-5 (2019).

  11. Fichou, Y. et al. Proc. Natl Acad. Sci. USA 115, 13234–13239 (2018).

    Article  CAS  Google Scholar 

  12. Zhang, W. et al. eLife 8, e43584 (2019).

    Article  Google Scholar 

  13. Fichou, Y., Vigers, M., Goring, A. K., Eschmann, N. A. & Han, S. Chem. Commun. (Camb.) 54, 4573–4576 (2018).

    Article  CAS  Google Scholar 

  14. Mukrasch, M. D. et al. PLoS Biol. 7, e1000034 (2009).

    Article  Google Scholar 

  15. Peterson, D. W., Zhou, H., Dahlquist, F. W. & Lew, J. Biochemistry 47, 7393–7404 (2008).

    Article  CAS  Google Scholar 

  16. Landrieu, I. et al. J. Am. Chem. Soc. 128, 3575–3583 (2006).

    Article  CAS  Google Scholar 

  17. Akoury, E. et al. J. Am. Chem. Soc. 135, 2853–2862 (2013).

    Article  CAS  Google Scholar 

  18. Daebel, V. et al. J. Am. Chem. Soc. 134, 13982–13989 (2012).

    Article  CAS  Google Scholar 

  19. Margittai, M. & Langen, R. Proc. Natl Acad. Sci. USA 101, 10278–10283 (2004).

    Article  CAS  Google Scholar 

  20. Meyer, V. et al. J. Biol. Chem. 291, 12271–12281 (2016).

    Article  CAS  Google Scholar 

  21. Eschmann, N. et al. Sci. Rep. 7, 44739 (2017).

    Article  Google Scholar 

Download references

Acknowledgements

Y.F. is supported by the National Institute of Aging of the US National Institutes of Health (NIH) through grant R01AG05605. S.H. acknowledges support of that NIH grant R01AG05605 and the Tau Consortium of the Rainwater Charitable Foundation.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Songi Han.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Fichou, Y., Han, S. Protein shapes at the core of chronic traumatic encephalopathy. Nat Struct Mol Biol 26, 336–338 (2019). https://doi.org/10.1038/s41594-019-0221-2

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41594-019-0221-2

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing