Supplementary Figure 6: Also a reduced overlap between Xist and Tsix as in the human locus allows mono-allelic up-regulation of Xist. | Nature Structural & Molecular Biology

Supplementary Figure 6: Also a reduced overlap between Xist and Tsix as in the human locus allows mono-allelic up-regulation of Xist.

From: A symmetric toggle switch explains the onset of random X inactivation in different mammals

Supplementary Figure 6

(a, c) Schematic representation of the Xist-Tsix locus architecture in the mouse (a) and the human (c) genome, respectively. (b, d) Distribution of the mean frequency of mono-allelic Xist up-regulation across all parameter sets tested, in simulations assuming the locus architecture shown in (a) and (c), respectively. For details see Supplementary Note 1 (section 3.5). (e, f) Simulation of Xist up-regulation using the model with the human locus architecture in (c) for one example parameter set, showing three individual cells (e) and a population of 100 cells (f). Light and dark green in (e) represent Xist levels expressed from the two X chromosomes, light and dark grey in (f) represent mono- and bi-allelic Xist expression, as indicated.