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ERα condensates: chronic stimulation is hard to ignore

Nature Structural & Molecular Biology volume 26, pages 153–154 (2019)Cite this article

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Last year, several studies reported that proteins form biomolecular condensates at gene enhancers. Nair et al. now show that these condensates undergo physical changes over time, which affects their nuclear localization and the transcriptional output of their target genes.

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Fig. 1: Model depicting how enhancer condensates are formed and how they lead to the activation of transcription.

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Authors and Affiliations

  1. Max-Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany

    Sina Wittmann & Simon Alberti

  2. Biotechnology Center (BIOTEC), Center for Molecular and Cellular Bioengineering (CMCB), Technische Universität Dresden, Dresden, Germany

    Simon Alberti

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  1. Sina Wittmann
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  2. Simon Alberti
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Correspondence to Simon Alberti.

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Competing interests

S.A. is a scientific advisor of Dewpoint Therapeutics.

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Wittmann, S., Alberti, S. ERα condensates: chronic stimulation is hard to ignore. Nat Struct Mol Biol 26, 153–154 (2019). https://doi.org/10.1038/s41594-019-0198-x

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