Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:


Crisis management by autophagy

Autophagy is a highly contextual modulator of tumorigenesis. A new study shows that autophagy can serve as a tumor suppressor to mediate cell death at replicative crisis.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Two-stage immortalization and autophagy.


  1. White, E., Mehnert, J. M. & Chan, C. S. Clin. Cancer Res. 21, 5037–5046 (2015).

    Article  CAS  Google Scholar 

  2. Nassour, J. et al. Nature (2019).

  3. Wright, W. E. & Shay, J. W. Exp. Gerontol. 27, 383–389 (1992).

    Article  CAS  Google Scholar 

  4. Cesare, A. J. & Karlseder, J. Curr. Opin. Cell Biol. 24, 731–738 (2012).

    Article  CAS  Google Scholar 

  5. Fumagalli, M. et al. Nat. Cell Biol. 14, 355–365 (2012).

    Article  CAS  Google Scholar 

  6. Hewitt, G. et al. Nat. Commun. 3, 708 (2012).

    Article  Google Scholar 

  7. Maciejowski, J. & de Lange, T. Nat. Rev. Mol. Cell Biol. 18, 175–186 (2017).

    Article  CAS  Google Scholar 

  8. Hanahan, D. & Weinberg, R. A. Cell 144, 646–674 (2011).

    Article  CAS  Google Scholar 

  9. Li, T. & Chen, Z. J. J. Exp. Med. 215, 1287–1299 (2018).

    Article  CAS  Google Scholar 

  10. Watson, R. O., Manzanillo, P. S. & Cox, J. S. Cell 150, 803–815 (2012).

    Article  CAS  Google Scholar 

  11. Liang, Q. et al. Cell Host Microbe 15, 228–238 (2014).

    Article  CAS  Google Scholar 

  12. Ivanov, A. et al. J. Cell Biol. 202, 129–143 (2013).

    Article  CAS  Google Scholar 

  13. Dou, Z. et al. Nature 527, 105–109 (2015).

    Article  CAS  Google Scholar 

  14. Doherty, J. & Baehrecke, E. H. Nat. Cell Biol. 20, 1110–1117 (2018).

    Article  CAS  Google Scholar 

  15. Cuervo, A. M. Trends Genet. 24, 604–612 (2008).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Masashi Narita.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Narita, M. Crisis management by autophagy. Nat Struct Mol Biol 26, 151–152 (2019).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing