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AUTOPHAGY

Crisis management by autophagy

Autophagy is a highly contextual modulator of tumorigenesis. A new study shows that autophagy can serve as a tumor suppressor to mediate cell death at replicative crisis.

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Fig. 1: Two-stage immortalization and autophagy.

References

  1. White, E., Mehnert, J. M. & Chan, C. S. Clin. Cancer Res. 21, 5037–5046 (2015).

    Article  CAS  Google Scholar 

  2. Nassour, J. et al. Nature https://www.nature.com/articles/s41586-019-0885-0 (2019).

  3. Wright, W. E. & Shay, J. W. Exp. Gerontol. 27, 383–389 (1992).

    Article  CAS  Google Scholar 

  4. Cesare, A. J. & Karlseder, J. Curr. Opin. Cell Biol. 24, 731–738 (2012).

    Article  CAS  Google Scholar 

  5. Fumagalli, M. et al. Nat. Cell Biol. 14, 355–365 (2012).

    Article  CAS  Google Scholar 

  6. Hewitt, G. et al. Nat. Commun. 3, 708 (2012).

    Article  Google Scholar 

  7. Maciejowski, J. & de Lange, T. Nat. Rev. Mol. Cell Biol. 18, 175–186 (2017).

    Article  CAS  Google Scholar 

  8. Hanahan, D. & Weinberg, R. A. Cell 144, 646–674 (2011).

    Article  CAS  Google Scholar 

  9. Li, T. & Chen, Z. J. J. Exp. Med. 215, 1287–1299 (2018).

    Article  CAS  Google Scholar 

  10. Watson, R. O., Manzanillo, P. S. & Cox, J. S. Cell 150, 803–815 (2012).

    Article  CAS  Google Scholar 

  11. Liang, Q. et al. Cell Host Microbe 15, 228–238 (2014).

    Article  CAS  Google Scholar 

  12. Ivanov, A. et al. J. Cell Biol. 202, 129–143 (2013).

    Article  CAS  Google Scholar 

  13. Dou, Z. et al. Nature 527, 105–109 (2015).

    Article  CAS  Google Scholar 

  14. Doherty, J. & Baehrecke, E. H. Nat. Cell Biol. 20, 1110–1117 (2018).

    Article  CAS  Google Scholar 

  15. Cuervo, A. M. Trends Genet. 24, 604–612 (2008).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Masashi Narita.

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Narita, M. Crisis management by autophagy. Nat Struct Mol Biol 26, 151–152 (2019). https://doi.org/10.1038/s41594-019-0195-0

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