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Respiratory supercomplexes III2IV2 come into focus

Structural information on the respiratory supercomplex III2IV2 from budding yeast and from Mycobacterium smegmatis has become available, with cryo-EM work from four different groups.

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References

  1. 1.

    Gu, J. et al. Nature 537, 639–643 (2016).

  2. 2.

    Letts, J. A., Fiedorczuk, K. & Sazanov, L. A. Nature 537, 644–648 (2016).

  3. 3.

    Sousa, J. S., Mills, D. J., Vonck, J. & Kühlbrandt, W. eLife 5, e21290 (2016).

  4. 4.

    Guo, R., Zong, S., Wu, M., Gu, J. & Yang, M. Cell 170, 1247–1257.e12 (2017).

  5. 5.

    Davies, K. M., Blum, T. B. & Kühlbrandt, W. Proc. Natl Acad. Sci. USA 115, 3024–3029 (2018).

  6. 6.

    Mileykovskaya, E. et al. J. Biol. Chem. 287, 23095–23103 (2012).

  7. 7.

    Rathore, S. et al. Nat. Struct. Mol. Biol. 26, 50–57 (2019).

  8. 8.

    Hartley, A. M. et al. Nat. Struct. Mol. Biol. 26, 78–83 (2019).

  9. 9.

    Wiseman, B. et al. Nat. Struct. Mol. Biol. 25, 1128–1136 (2018).

  10. 10.

    Gong, H. et al. Science 362, eaat8923 (2018).

  11. 11.

    Schägger, H. & Pfeiffer, K. EMBO J. 19, 1777–1783 (2000).

  12. 12.

    Heinemeyer, J., Braun, H. P., Boekema, E. J. & Kouril, R. J. Biol. Chem. 282, 12240–12248 (2007).

  13. 13.

    Zhang, M., Mileykovskaya, E. & Dowhan, W. J. Biol. Chem. 277, 43553–43556 (2002).

  14. 14.

    Pfeiffer, K. et al. J. Biol. Chem. 278, 52873–52880 (2003).

  15. 15.

    Hunte, C., Koepke, J., Lange, C., Rossmanith, T. & Michel, H. Structure 8, 669–684 (2000).

  16. 16.

    Levchenko, M. et al. Cell Res. 1863, 1624–1632 (2016).

  17. 17.

    Strecker, V. et al. Cell Res. 1863, 1643–1652 (2016).

  18. 18.

    Megehee, J. A., Hosler, J. P. & Lundrigan, M. D. Microbiology 152, 823–829 (2006).

  19. 19.

    Kao, W.-C. et al. Biochim. Biophys. Acta Bioenerg. 1857, 1705–1714 (2016).

  20. 20.

    Iwata, S. et al. Science 281, 64–71 (1998).

  21. 21.

    Castellani, M. et al. J. Biol. Chem. 285, 502–510 (2010).

  22. 22.

    Sun, C. et al. Nature 557, 123–126 (2018).

  23. 23.

    Sousa, J. S. et al. Nat. Commun. 9, 1728 (2018).

  24. 24.

    Genova, M. L. & Lenaz, G. Antioxid. Redox Signal. 23, 208–238 (2015).

  25. 25.

    Suthammarak, W., Somerlot, B. H., Opheim, E., Sedensky, M. & Morgan, P. G. Aging Cell 12, 1132–1140 (2013).

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Correspondence to Janet Vonck.

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Fig. 1: Architecture of III2IV2 supercomplexes.
Fig. 2: Electron transfer in III2IV2 supercomplexes.
Fig. 3: Interaction of complex III and IV in supercomplexes.