Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

BIOENERGETICS

Respiratory supercomplexes III2IV2 come into focus

Nature Structural & Molecular Biology volume 26, pages 87–89 (2019)Cite this article

Subjects

Structural information on the respiratory supercomplex III2IV2 from budding yeast and from Mycobacterium smegmatis has become available, with cryo-EM work from four different groups.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Architecture of III2IV2 supercomplexes.
Fig. 2: Electron transfer in III2IV2 supercomplexes.
Fig. 3: Interaction of complex III and IV in supercomplexes.

References

  1. Gu, J. et al. Nature 537, 639–643 (2016).

    Article  CAS  Google Scholar 

  2. Letts, J. A., Fiedorczuk, K. & Sazanov, L. A. Nature 537, 644–648 (2016).

    Article  CAS  Google Scholar 

  3. Sousa, J. S., Mills, D. J., Vonck, J. & Kühlbrandt, W. eLife 5, e21290 (2016).

    Article  Google Scholar 

  4. Guo, R., Zong, S., Wu, M., Gu, J. & Yang, M. Cell 170, 1247–1257.e12 (2017).

    Article  CAS  Google Scholar 

  5. Davies, K. M., Blum, T. B. & Kühlbrandt, W. Proc. Natl Acad. Sci. USA 115, 3024–3029 (2018).

    Article  CAS  Google Scholar 

  6. Mileykovskaya, E. et al. J. Biol. Chem. 287, 23095–23103 (2012).

    Article  CAS  Google Scholar 

  7. Rathore, S. et al. Nat. Struct. Mol. Biol. 26, 50–57 (2019).

    Article  Google Scholar 

  8. Hartley, A. M. et al. Nat. Struct. Mol. Biol. 26, 78–83 (2019).

    Article  Google Scholar 

  9. Wiseman, B. et al. Nat. Struct. Mol. Biol. 25, 1128–1136 (2018).

    Article  CAS  Google Scholar 

  10. Gong, H. et al. Science 362, eaat8923 (2018).

    Article  Google Scholar 

  11. Schägger, H. & Pfeiffer, K. EMBO J. 19, 1777–1783 (2000).

    Article  Google Scholar 

  12. Heinemeyer, J., Braun, H. P., Boekema, E. J. & Kouril, R. J. Biol. Chem. 282, 12240–12248 (2007).

    Article  CAS  Google Scholar 

  13. Zhang, M., Mileykovskaya, E. & Dowhan, W. J. Biol. Chem. 277, 43553–43556 (2002).

    Article  CAS  Google Scholar 

  14. Pfeiffer, K. et al. J. Biol. Chem. 278, 52873–52880 (2003).

    Article  CAS  Google Scholar 

  15. Hunte, C., Koepke, J., Lange, C., Rossmanith, T. & Michel, H. Structure 8, 669–684 (2000).

    Article  CAS  Google Scholar 

  16. Levchenko, M. et al. Cell Res. 1863, 1624–1632 (2016).

    CAS  Google Scholar 

  17. Strecker, V. et al. Cell Res. 1863, 1643–1652 (2016).

    CAS  Google Scholar 

  18. Megehee, J. A., Hosler, J. P. & Lundrigan, M. D. Microbiology 152, 823–829 (2006).

    Article  CAS  Google Scholar 

  19. Kao, W.-C. et al. Biochim. Biophys. Acta Bioenerg. 1857, 1705–1714 (2016).

    Article  CAS  Google Scholar 

  20. Iwata, S. et al. Science 281, 64–71 (1998).

    Article  CAS  Google Scholar 

  21. Castellani, M. et al. J. Biol. Chem. 285, 502–510 (2010).

    Article  CAS  Google Scholar 

  22. Sun, C. et al. Nature 557, 123–126 (2018).

    Article  CAS  Google Scholar 

  23. Sousa, J. S. et al. Nat. Commun. 9, 1728 (2018).

    Article  Google Scholar 

  24. Genova, M. L. & Lenaz, G. Antioxid. Redox Signal. 23, 208–238 (2015).

    Article  CAS  Google Scholar 

  25. Suthammarak, W., Somerlot, B. H., Opheim, E., Sedensky, M. & Morgan, P. G. Aging Cell 12, 1132–1140 (2013).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Structural Biology, Max Planck Institute of Biophysics, Frankfurt am Main, Germany

    Joana S. Sousa & Janet Vonck

Authors
  1. Joana S. Sousa
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Janet Vonck
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Janet Vonck.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sousa, J.S., Vonck, J. Respiratory supercomplexes III2IV2 come into focus. Nat Struct Mol Biol 26, 87–89 (2019). https://doi.org/10.1038/s41594-019-0184-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41594-019-0184-3

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing