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Nucleosome structure and dynamics are coming of age

Nature Structural & Molecular Biology volume 26, pages 3–13 (2019)Cite this article

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Abstract

Since the first high-resolution structure of the nucleosome was reported in 1997, the available information on chromatin structure has increased very rapidly. Here, we review insights derived from cutting-edge biophysical and structural approaches applied to the study of nucleosome dynamics and nucleosome-binding factors, with a focus on the experimental advances driving the research. In addition, we highlight emerging challenges in nucleosome structural biology.

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Fig. 1: Nucleosome structure.
Fig. 2: Dynamics of nucleosome unwrapping.
Fig. 3: Structures of chromatin-binding factor complexes.

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Acknowledgements

We thank our colleagues J. W. Markert and U. M. Muthurajan for critical reading of this Review. Research in the laboratory of K.L. is supported by the Howard Hughes Medical Institute and by the NIH (CA218255).

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  1. These authors contributed equally: Keda Zhou, Guillaume Gaullier.

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  1. Department of Biochemistry, University of Colorado Boulder, Boulder, CO, USA

    Keda Zhou, Guillaume Gaullier & Karolin Luger

  2. Howard Hughes Medical Institute, University of Colorado Boulder, Boulder, CO, USA

    Guillaume Gaullier & Karolin Luger

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Zhou, K., Gaullier, G. & Luger, K. Nucleosome structure and dynamics are coming of age. Nat Struct Mol Biol 26, 3–13 (2019). https://doi.org/10.1038/s41594-018-0166-x

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