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Deconstructing transport-distribution reconstruction in the nuclear-pore complex

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References

  1. 1.

    Wente, S. R. & Rout, M. P. Cold Spring Harb. Perspect. Biol. 2, a000562 (2010).

  2. 2.

    Ma, J., Goryaynov, A. & Yang, W. Nat. Struct. Mol. Biol. 23, 239–247 (2016).

  3. 3.

    Ma, J. & Yang, W. Proc. Natl Acad. Sci. USA 107, 7305–7310 (2010).

  4. 4.

    Ma, J., Goryaynov, A., Sarma, A. & Yang, W. Proc. Natl Acad. Sci. USA 109, 7326–7331 (2012).

  5. 5.

    Ma, J. et al. Nat. Commun. 4, 2414 (2013).

  6. 6.

    Goryaynov, A. & Yang, W. PLoS One 9, e88792 (2014).

  7. 7.

    Kelich, J. M. et al. Mol. Ther. Methods Clin. Dev. 2, 15047 (2015).

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Acknowledgements

This work was funded by grants 1R01GM123541. D.G. acknowledges support from the National Institutes of Health Common Fund 4D Nucleome Program (grant 1U01EB021238) and NIGMS grant R01GM123541. C.S.S. was supported by a Junior Research Fellowship through Merton College, Oxford, UK. We thank S. Musser for critical feedback on the entire project and M. Hammer for critical reading of theory development. L.-C.T. acknowledges support by the NIH through grant K99 GM126810.

Author information

All authors contributed to the study design and data interpretation; L.-C.T., M.H., C.S.S. and Y.-C.C. collected and analyzed data, M.H. led and implemented simulations with support from C.S.S. and Y.-C.C.; Y.-C.C. derived theory with support from L.-C.T. and C.S.S. D.G. initiated the project and provided supervision. All authors wrote, revised, and approved the manuscript.

Correspondence to David Grunwald.

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The authors declare no competing interests.

Supplementay Infomation

Supplementary Note 1

Theoretical description and analysis of 3D SPEED

Reporting Summary

Supplementary Note 2

Supplemental simulation results

Supplementary Note 3

Simulation methods

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Further reading

Fig. 1: The performance of SPEED depends on the dataset size and overall precision.