Attempts to develop a method for 3D genome reconstruction of single cells have been frustrated by the inability to distinguish between chromosome homologs. A novel Hi-C workflow uses haplotype imputation to map the nuclear organization of single diploid cells.
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Caldwell, B.A., Bartolomei, M.S. Mapping the diploid genome, one cell at a time. Nat Struct Mol Biol 25, 994–995 (2018). https://doi.org/10.1038/s41594-018-0149-y
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DOI: https://doi.org/10.1038/s41594-018-0149-y