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Epitranscriptome regulation

Nature Structural & Molecular Biology (2018)Cite this article

Dynamic modifications of RNAs play essential regulatory roles during RNA-processing events and thereby affect gene expression as well as cellular functions, development and diseases such as cancer. Dan Dominissini and Gideon Rechavi illustrate the broad relevance of ‘epitranscriptome regulation’, as this phenomenon is now known, using as an example the functions and mechanisms of action of N 6-methyladenosine (m6A), an abundant and well-studied RNA modification.

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  1. Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

    Dan Dominissini & Gideon Rechavi

  2. Cancer Research Center and Wohl Institute for Translational Medicine, Chaim Sheba Medical Center, Tel-Hashomer, Israel

    Dan Dominissini & Gideon Rechavi

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  1. Dan Dominissini
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  2. Gideon Rechavi
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Correspondence to Dan Dominissini or Gideon Rechavi.

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Dominissini, D., Rechavi, G. Epitranscriptome regulation. Nat Struct Mol Biol (2018). https://doi.org/10.1038/s41594-018-0140-7

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  • DOI: https://doi.org/10.1038/s41594-018-0140-7

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