Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

RNA MODIFICATIONS

U-tail as a guardian against invading RNAs

Nature Structural & Molecular Biology volume 25, pages 903–905 (2018)Cite this article

Subjects

RNA uridylation offers a basis for diverse post-transcriptional regulation. Two recent studies reveal new roles of uridylation in immune defense against viruses and retrotransposons.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Uridylation has diverse roles in RNA metabolism.
Fig. 2: Terminal uridyltransferases restrict viruses and retrotransposons.

References

  1. Lim, J. et al. Science 361, 701–704 (2018).

    Article  CAS  Google Scholar 

  2. De Almeida, C., Scheer, H., Zuber, H. & Gagliardi, D. Wiley Interdiscip. Rev. RNA 9, e1440 (2018).

    Article  Google Scholar 

  3. Scheer, H., Zuber, H., De Almeida, C. & Gagliardi, D. Trends Genet. 32, 607–619 (2016).

    Article  CAS  Google Scholar 

  4. Trippe, R., Sandrock, B. & Benecke, B. J. Nucleic Acids Res. 26, 3119–3126 (1998).

    Article  CAS  Google Scholar 

  5. Mroczek, S. & Dziembowski, A. Wiley Interdiscip. Rev. RNA 4, 581–592 (2013).

    Article  CAS  Google Scholar 

  6. Heo, I. et al. Cell 151, 521–532 (2012).

    Article  CAS  Google Scholar 

  7. Lim, J. et al. Cell 159, 1365–1376 (2014).

    Article  CAS  Google Scholar 

  8. Scott, D. D. & Norbury, C. J. Biochim. Biophys. Acta 1829, 654–665 (2013).

    Article  CAS  Google Scholar 

  9. Rissland, O. S., Mikulasova, A. & Norbury, C. J. Mol. Cell. Biol. 27, 3612–3624 (2007).

    Article  CAS  Google Scholar 

  10. Sement, F. M. et al. Nucleic Acids Res. 41, 7115–7127 (2013).

    Article  CAS  Google Scholar 

  11. Chang, H. et al. Mol. Cell 70, 72–82 (2018).

    Article  CAS  Google Scholar 

  12. Morgan, M. et al. Nature 548, 347–351 (2017).

    Article  CAS  Google Scholar 

  13. Huo, Y. et al. Sci. Rep. 6, 25454 (2016).

    Article  CAS  Google Scholar 

  14. Le Pen, J. et al. Nat. Struct. Mol. Biol. 25, 778–786 (2018).

    Article  Google Scholar 

  15. Warkocki, Z. et al. Cell 174, 1537–1548 (2018).

    Article  CAS  Google Scholar 

  16. Ashe, A. et al. eLife 2, e00994 (2013).

    Article  Google Scholar 

  17. Molleston, J. M. et al. Genes Dev. 30, 1658–1670 (2016).

    Article  CAS  Google Scholar 

  18. Cost, G. J., Feng, Q., Jacquier, A. & Boeke, J. D. EMBO J. 21, 5899–5910 (2002).

    Article  CAS  Google Scholar 

  19. Feng, Q., Moran, J. V., Kazazian, H. H. Jr. & Boeke, J. D. Cell 87, 905–916 (1996).

    Article  CAS  Google Scholar 

  20. Goodier, J. L. Mob. DNA 7, 16 (2016).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Center for RNA Research, Institute for Basic Science, Seoul, Korea

    Jinah Yeo & V. Narry Kim

  2. School of Biological Sciences, Seoul National University, Seoul, Korea

    V. Narry Kim

Authors
  1. Jinah Yeo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. Narry Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to V. Narry Kim.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Yeo, J., Kim, V.N. U-tail as a guardian against invading RNAs. Nat Struct Mol Biol 25, 903–905 (2018). https://doi.org/10.1038/s41594-018-0139-0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41594-018-0139-0

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing