Supplementary Figure 11: b12 disrupts the interactions between CD4 and co-receptors. | Nature Structural & Molecular Biology

Supplementary Figure 11: b12 disrupts the interactions between CD4 and co-receptors.

From: A dynamic three-step mechanism drives the HIV-1 pre-fusion reaction

Supplementary Figure 11

Use of the interaction factor (IF) as defined in the Methods reveals that both CD4 and CXCR4 or CCR5 give similar IF values as untreated cells (first column). A t test to evaluate the average of interacting (n = 8) and non-interacting (n = 5) cells was performed between the first two columns from the left. At 0.05 confidence, the means are statistically different.

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