Supplementary Figure 7: Addition of CXCL12 and OKT4 inhibits both positive Bcc and HIV-1 fusion. | Nature Structural & Molecular Biology

Supplementary Figure 7: Addition of CXCL12 and OKT4 inhibits both positive Bcc and HIV-1 fusion.

From: A dynamic three-step mechanism drives the HIV-1 pre-fusion reaction

Supplementary Figure 7

a–e, The addition of 100 nM CXCL12 (CXCR4 ligand) and OKT4 (50 μg/mL) blocks both time-resolved cross-variance signal (a–d) and the colocalization between HIVHXB2 and Bcc micrographs (e). f, Infection assays of COS-7 cells co-expressing CD4 and CXCR4 also show that productive infection is also blocked by 100 nM CXCL12 (CXCR4 ligand) and OKT4 (50 μg/mL). Scale bars, 300 nm.

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