Supplementary Figure 4: CD4-mOrange and CXCR4-mTFP1 are mostly monomers and dimers before exposure to HIV-1 virions. | Nature Structural & Molecular Biology

Supplementary Figure 4: CD4-mOrange and CXCR4-mTFP1 are mostly monomers and dimers before exposure to HIV-1 virions.

From: A dynamic three-step mechanism drives the HIV-1 pre-fusion reaction

Supplementary Figure 4

Box plot showing the average oligomeric state throughout the entire COS-7 cell surface for CD4-mOrange before and after HIV-1HXB2 (mostly monomers) virion addition (red dots) (mostly trimers) and CXCR4-mTFP1 (red dots) before (average monomers) and after HIV-1HXB2 (average dimers). The 0.05 level for one-way ANOVA shows that the population means are significantly different. b, Scatterplot showing the CD4–CXCR4 oligomeric states before (red dots) and after HIV-1HXB2 exposure. Each dot is the average oligomeric state taking the mean throughout the cells.

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