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DNA DAMAGE RESPONSE

Switching 53BP1 on and off via Tudors

In a stress-free environment, the histone binding function of 53BP1 is inhibited by TIRR, but upon DNA damage 53BP1 is recruited to chromatin and promotes DNA repair. New structural studies provide insights into the mechanisms underlying 53BP1 inhibition and activation. TIRR physically blocks the methyl-lysine histone-binding site of Tudors, and RNA binding by TIRR alleviates this block.

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Fig. 1: A model for switching 53BP1 on and off via Tudors.

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Correspondence to Tatiana G. Kutateladze.

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Zhang, Y., Kutateladze, T.G. Switching 53BP1 on and off via Tudors. Nat Struct Mol Biol 25, 646–647 (2018). https://doi.org/10.1038/s41594-018-0104-y

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