Under steady-state conditions, the E3 ubiquitin ligase Parkin is localized to the cytosol in an autoinhibited state. Two recent studies describe the mechanism of Parkin activation by phosphorylation via structural rearrangement of the Ubl and RING2 domains, explaining how the RING2 domain is released from the core of Parkin to allow for ubiquitination of its substrates.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Kalia, L. V. & Lang, A. E. Lancet 386, 896–912 (2015).
Kitada, T. et al. Nature 392, 605–608 (1998).
Valente, E. M. et al. Science 304, 1158–1160 (2004).
Seirafi, M., Kozlov, G. & Gehring, K. FEBS J. 282, 2076–2088 (2015).
Narendra, D. P. et al. PLoS Biol. 8, e1000298 (2010).
Shiba-Fukushima, K. et al. PLoS Genet. 10, e1004861 (2014).
Kazlauskaite, A. et al. EMBO Rep. 16, 939–954 (2015).
Kane, L. A. et al. J. Cell Biol. 205, 143–153 (2014).
Kazlauskaite, A. et al. Biochem. J. 460, 127–139 (2014).
Koyano, F. et al. Nature 510, 162–166 (2014).
Ordureau, A. et al. Mol. Cell 56, 360–375 (2014).
Wauer, T., Simicek, M., Schubert, A. & Komander, D. Nature 524, 370–374 (2015).
Trempe, J. F. et al. Science 340, 1451–1455 (2013).
Kumar, A. et al. Nat. Struct. Mol. Biol. 24, 475–483 (2017).
Sauvé, V. et al. Nat. Struct. Mol. Biol. 25, 623–630 (2018).
Gladkova, C., Maslen, S. L., Skehel, J. M. & Komander, D. Nature 559, 410–414 (2018).
Sarraf, S. A. et al. Nature 496, 372–376 (2013).
Ordureau, A. et al. Mol. Cell 70, 211–227 (2018).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Le Guerroué, F., Youle, R.J. Active state of Parkin. Nat Struct Mol Biol 25, 644–646 (2018). https://doi.org/10.1038/s41594-018-0101-1
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41594-018-0101-1
