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RNA decay

Molecular autopsy provides evidence for widespread ribosome-phased mRNA fragmentation

Recent developments in transcriptome-wide sequencing technologies have enabled the identification of cellular mRNA decay intermediates. Although canonical mRNA decay has been shown to occur by deadenylation followed by decapping and subsequent exonucleolytic decay from both mRNA ends, a study by Mourelatos and colleagues now defines mRNA fragments that are generated on polysomes by endonucleolytic cleavages phased by the associated ribosome.

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Acknowledgements

The authors thank M. Popp for comments on this manuscript. Work on mRNA decay in the Maquat laboratory is supported by R01 GM059614 and R37 GM074593, both to L.E.M.

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Correspondence to Lynne E. Maquat.

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Fig. 1: Model for HeLa cell ribothrypsis.