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Regeneration and repair of the nervous system

Astrocytes at the border of repair

Astrocytes have important roles in the repair of the CNS. However, the underlying mechanisms involved remain incompletely understood. O’Shea et al. report that the functional reprogramming of astrocytes at the borders of traumatic lesions contributes to the re-establishment of CNS integrity by separating the parenchyma from stromal and immune cells.

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Fig. 1: Functional reprogramming of wound repair astrocytes.

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Correspondence to Francisco J. Quintana.

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Lee, HG., Quintana, F.J. Astrocytes at the border of repair. Nat Neurosci (2024). https://doi.org/10.1038/s41593-024-01670-y

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