Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Spinal cord injury

Each scar whispers a story

After spinal cord injury, stromal fibroblasts originate from pericytes and perivascular fibroblasts, with pericytes more prevalent in gray matter and fibroblasts in white matter. Holl et al. show that both cell types respond to injury and inflammation, are activated, and transcriptionally converge on scar formation after injury, paving the way for therapeutic possibilities.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Scar formation in the nervous system presents distinct and region-dependent features.

References

  1. Ayazi, M., Zivkovic, S., Hammel, G., Stefanovic, B. & Ren, Y. Cells 11, 2371 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Dorrier, C. E., Jones, H. E., Pintarić, L., Siegenthaler, J. A. & Daneman, R. Nat. Rev. Neurosci. 23, 23–34 (2022).

    Article  CAS  PubMed  Google Scholar 

  3. Dias, D. O. et al. Nat. Commun. 12, 5501 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. D’Ambrosi, N. & Apolloni, S. Front. Immunol. 11, 1394 (2020).

    Article  PubMed  PubMed Central  Google Scholar 

  5. Adams, K. L. & Gallo, V. Nat. Neurosci. 21, 9–15 (2018).

    Article  CAS  PubMed  Google Scholar 

  6. Voskuhl, R. R. et al. J. Neurosci. 29, 11511–11522 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Fernández-Klett, F. & Priller, J. Brain Pathol. 24, 404–413 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  8. Holl, D. et al. Nat. Neurosci. https://doi.org/10.1038/s41593-024-01678-4 (2024).

  9. Comi, G. et al. Lancet Neurol. 18, 1009–1020 (2019).

    Article  CAS  PubMed  Google Scholar 

  10. Ferreira, J. J. et al. Lancet Neurol. 15, 154–165 (2016).

    Article  CAS  PubMed  Google Scholar 

  11. Hill, M. D. et al. Lancet 395, 878–887 (2020).

    Article  CAS  PubMed  Google Scholar 

  12. Kawabori, M., Shichinohe, H., Kuroda, S. & Houkin, K. Int. J. Mol. Sci. 21, 7380 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Daly, E. J. et al. JAMA Psychiatry 76, 893–903 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  14. Juul, S. E. et al. N. Engl. J. Med. 382, 233–243 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

We thank G. Simonti for help with Fig. 1.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Vittorio Gallo.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Gallo, V., Kratimenos, P. Each scar whispers a story. Nat Neurosci 27, 1215–1216 (2024). https://doi.org/10.1038/s41593-024-01665-9

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41593-024-01665-9

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing