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Dissecting the epigenetic regulation of human brain organoid development in single cells

We present a developmental atlas that offers insight into sequential epigenetic changes underlying early human brain development modeled in organoids, which reconstructs the differentiation trajectories of all major CNS regions. It shows that epigenetic regulation via the installation of activating histone marks precedes activation of groups of neuronal genes.

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Fig. 1: Tracking chromatin dynamics throughout differentiation.


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This is a summary of: Zenk, F. et al. Single-cell epigenomic reconstruction of developmental trajectories from pluripotency in human neural organoid systems. Nat. Neurosci. (2024).

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Dissecting the epigenetic regulation of human brain organoid development in single cells. Nat Neurosci 27, 1219–1220 (2024).

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