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Genetic ancestry contributes to gene expression in the brain

By using genetic admixture in the multi-omic analysis of postmortem brains from Black Americans, we show that genetic ancestry influences gene expression in the brain. Notably, we find enrichment of ancestry-associated genes for immune response and vascular function, but not neuronal function. Our findings have potential implications for stroke, Parkinson’s disease and Alzheimer’s disease.

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Fig. 1: Genetic variation drives genetic ancestry expression changes.


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This is a summary of: Benjamin, K. J. M. et al. Analysis of gene expression in the postmortem brain of neurotypical Black Americans reveals contributions of genetic ancestry. Nat. Neurosci. (2024).

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Genetic ancestry contributes to gene expression in the brain. Nat Neurosci 27, 1042–1043 (2024).

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