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Three patterns link brain organization to genes in health and disease

Gene expression in the human cortex is shown to exhibit a generalizable three-component architecture that reflects neuronal, metabolic, and immune programmes of healthy brain development. The three components have distinct associations with autism spectrum disorder and schizophrenia, revealing connections between previously unrelated results from studies of case–control neuroimaging, differential gene expression, and genetic risk.

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Fig. 1: Three components of gene expression reveal convergent links between healthy brain organization and neurodevelopmental disorders.

References

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This is a summary of: Dear, R. et al. Cortical gene expression architecture links healthy neurodevelopment to the imaging, transcriptomics and genetics of autism and schizophrenia. Nat. Neurosci. https://doi.org/10.1038/s41593-024-01624-4 (2024).

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Three patterns link brain organization to genes in health and disease. Nat Neurosci 27, 1044–1045 (2024). https://doi.org/10.1038/s41593-024-01625-3

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