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Widespread changes in alternative splicing in developing and adult mouse brain

In the first comprehensive mRNA isoform atlas of the developing and adult mouse brain, we discover that region and age influence the isoform repertoire of cell subtypes. We link peak cell type regulation to the critical development period and report attenuated levels in adulthood.

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Fig. 1: Isoform variability in excitatory neurons.

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This is a summary of: Joglekar, A. et al. Single-cell long-read sequencing-based mapping reveals specialized splicing patterns in developing and adult mouse and human brain. Nat. Neurosci. https://doi.org/10.1038/s41593-024-01616-4 (2024).

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Widespread changes in alternative splicing in developing and adult mouse brain. Nat Neurosci 27, 1040–1041 (2024). https://doi.org/10.1038/s41593-024-01617-3

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