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Astrocyte biology

The silence of the reactive astrocytes

Astrocytes have important roles in disease and are difficult to modulate, owing to a paucity of known targets. Clayton et al. develop a screening platform to unbiasedly identify modulators of astrocyte reactivity. They discover that HDAC3 inhibitors regulate astrocyte transitions into their reactive phenotype in vitro and in vivo.

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Fig. 1: Experimental workflow designed to understand the mechanisms that regulate the formation of neurotoxic reactive astrocytes and how to revert their phenotype.


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Correspondence to Shane Liddelow.

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S.L. declares ownership of AstronauTx Ltd. F.L. declares no competing interests.

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Limone, F., Liddelow, S. The silence of the reactive astrocytes. Nat Neurosci 27, 607–609 (2024).

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