Multiple sclerosis (MS) is an autoimmune disease of the central nervous system that is driven by autoreactive lymphocytes. An in vivo CRISPR screen of T cell infiltration in a rat model of MS now identifies the genetic modules that control this key step in the immunopathology of MS.
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The authors declare no competing interests.
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Ali, M., Liston, A. Navigating T cell brain entry in MS. Nat Neurosci 26, 1661–1662 (2023). https://doi.org/10.1038/s41593-023-01433-1