We developed a 3D human neuroimmune axis model to study the interplay of brain innate immune cells and peripheral adaptive immune cells in Alzheimer’s disease. Alzheimer’s disease pathology induced a marked increase in CD8+ T cell infiltration, exacerbating neurodegeneration. The CXCL10–CXCR3 pathway has a key role in mediating this process.
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Jorfi, M. et al. The neuroimmune axis of Alzheimer’s disease. Genome Med 15, 6 (2023). This article reviews innate–adaptive immune interactions in AD.
Chen, X. et al. Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy. Nature 615, 668–677 (2023). This paper reports that microglia–T cell interactions promote neurodegeneration in a tauopathy model.
Gericke, C. et al. Early β-amyloid accumulation in the brain is associated with peripheral T cell alterations. Alzheimer’s Dement https://doi.org/10.1002/alz.13136 (2023). This paper reports an association of blood T cell increases with β-amyloid accumulation in cognitively healthy individuals.
Gate, D. et al. Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease. Nature 577, 399–404 (2020). This paper reports clonal expansion of CD8+ T cells in AD.
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This is a summary of: Jorfi, M. et al. Infiltrating CD8+ T cells exacerbate Alzheimer’s disease pathology in a 3D human neuroimmune axis model. Nat. Neurosci. https://doi.org/10.1038/s41593-023-01415-3 (2023)
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T cell–microglia signaling exacerbates neuropathology in an Alzheimer’s disease model. Nat Neurosci 26, 1487–1488 (2023). https://doi.org/10.1038/s41593-023-01417-1