Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

T cell–microglia signaling exacerbates neuropathology in an Alzheimer’s disease model

We developed a 3D human neuroimmune axis model to study the interplay of brain innate immune cells and peripheral adaptive immune cells in Alzheimer’s disease. Alzheimer’s disease pathology induced a marked increase in CD8+ T cell infiltration, exacerbating neurodegeneration. The CXCL10–CXCR3 pathway has a key role in mediating this process.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Infiltration of T cells in AD cellular models.


  1. Jorfi, M. et al. The neuroimmune axis of Alzheimer’s disease. Genome Med 15, 6 (2023). This article reviews innate–adaptive immune interactions in AD.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Chen, X. et al. Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy. Nature 615, 668–677 (2023). This paper reports that microglia–T cell interactions promote neurodegeneration in a tauopathy model.

    Article  CAS  PubMed  Google Scholar 

  3. Gericke, C. et al. Early β-amyloid accumulation in the brain is associated with peripheral T cell alterations. Alzheimer’s Dement (2023). This paper reports an association of blood T cell increases with β-amyloid accumulation in cognitively healthy individuals.

    Article  Google Scholar 

  4. Gate, D. et al. Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease. Nature 577, 399–404 (2020). This paper reports clonal expansion of CD8+ T cells in AD.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This is a summary of: Jorfi, M. et al. Infiltrating CD8+ T cells exacerbate Alzheimer’s disease pathology in a 3D human neuroimmune axis model. Nat. Neurosci. (2023)

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

T cell–microglia signaling exacerbates neuropathology in an Alzheimer’s disease model. Nat Neurosci 26, 1487–1488 (2023).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing