The Dominantly Inherited Alzheimer Network (DIAN) unites researchers aiming to understand autosomal dominant Alzheimer’s disease (ADAD). By longitudinally monitoring families worldwide, the DIAN Observational Study maintains an unprecedented resource of deeply phenotyped, freely available neuroimaging data on individuals with ADAD and their healthy relatives.
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Bekris, L. M. et al. Genetics of Alzheimer disease. J. Geriatr. Psychiatry Neurol. 23, 213–227 (2010). An overview of the clinical and genetic features of AD.
Bateman, R. J. et al. Clinical and biomarker changes in dominantly inherited Alzheimer’s disease. N. Engl. J. Med. 367, 795–804 (2012). An article using PET and MRI data from the DIAN-OBS to cross-sectionally establish the timing and order of pathophysiological changes prior to clinical symptom onset.
Gordon, B. A. et al. Spatial patterns of neuroimaging biomarker change in individuals from families with autosomal dominant Alzheimer’s disease: a longitudinal study. Lancet Neurol. 17, 241–250 (2018). An article describing longitudinal temporal trajectories and spatial patterns of ADAD pathology using PET and MRI data from the DIAN-OBS.
Millar, P. R. et al. Multimodal brain age estimates relate to Alzheimer disease biomarkers and cognition in early stages: a cross-sectional observational study. Elife 12, e81869 (2023). A study that integrated neuroimaging data of non-carriers from the DIAN-OBS with existing healthy control cohorts.
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This is a summary of: McKay, N. S. et al. Positron emission tomography and magnetic resonance imaging methods and datasets within the Dominantly Inherited Alzheimer Network (DIAN). Nat. Neurosci. https://doi.org/10.1038/s41593-023-01359-8 (2023).
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The Dominantly Inherited Alzheimer Network: A neuroimaging resource. Nat Neurosci 26, 1326–1327 (2023). https://doi.org/10.1038/s41593-023-01360-1