Zhu et al. show that basal forebrain cholinergic neurons send fast, specific information about a broad range of sensory stimuli to the auditory cortex, modulated by slower fluctuations in cholinergic activity. These findings help us to understand how the cholinergic system multiplexes diverse representations to fulfil its multifaceted roles in attention, learning and memory.
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Acknowledgements
This work was supported by the European Research Council Starting Grant no. 715043, NKFIH K 135561, the European Union project RRF-2.3.1-21-2022-00004 within the framework of the Artificial Intelligence National Laboratory and NAP3.0 of the Hungarian Academy of Sciences to B.H. and D.S.; and grants from the NIH (R00MH120047), Simons Foundation (872599SPI), Alfred P. Sloan Foundation (SP-2022-19027), and Scialog (29059 from the Research Corporation for Science Advancement and Walder Foundation) to L.P. We thank T. Ethan, K. Lex and H. Robinson for open access science art at SciDraw (https://doi.org/10.5281/zenodo.3925931 and https://doi.org/10.5281/zenodo.7058520).
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Schlingloff, D., Hangya, B. & Pinto, L. A cholinergic auditory pathway. Nat Neurosci 26, 726–728 (2023). https://doi.org/10.1038/s41593-023-01300-z
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DOI: https://doi.org/10.1038/s41593-023-01300-z
